Op-brai130244 3290..3304

Op-brai130244 1..15

1 Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK 2 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK 3 Human Cognitive Neuroscience, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK 4 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, ...

Silicone breast implants: the situation in 1991.

A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors.

PURPOSE Matrix metalloproteinases (MMP) play a fundamental role in cancer development and progression. S-3304 is a potent, orally active, noncytotoxic inhibitor of MMPs, primarily MMP-2 and MMP-9, that prolongs survival in mice xenografts and is well tolerated in healthy volunteers. EXPERIMENTAL DESIGN The aims of this phase I clinical trial were to determine the maximum tolerated dose, dose-...

Comparative tolerability, pharmacodynamics, and pharmacokinetics of a metabolite of a quinolizinone hypnotic and zolpidem in healthy subjects.

The objectives of this double-blind, placebo-controlled study were to assess the single dose tolerability, pharmacodynamics, and pharmacokinetics of Ro 41-3290 (5, 10, and 30 mg) and zolpidem (10 mg) in three sequential groups of 10 healthy male subjects. Pharmacodynamic (tracking, attention, and memory test) and pharmacokinetic measurements were conducted over a period of 24 and 50 h, respecti...

Intraamygdaloid administration of BIBO 3304 increases water intake and extends anxiolytic effects.

The present study was designed to evaluate the effects of BIBO 3304 in the Vogel's conflict drinking test and in the water intake test in non-deprived rats after injection of the drug into the basolateral nucleus of the amygdaloid complex. BIBO 3304 was given at the doses of 25, 100 and 200 pmol/0.5 microl/site. We investigated also the effect of 5-hydroxytryptophan (5-HTP), given intraperitone...